Dr. Henry G. Zot
Professor and Chair
Cell Physiology
hzot@westga.edu
678-839-4016
Education
- Ph.D. University of Miami
- M.S. University of Cincinnati
- B.A. Denison University
Research Interests
My laboratory has had a long-standing interest in how cells move and change shape. Complex movements such as crawling and contracting require coordination of events in all parts of the cell. Much of our current work revolves around the cytoskeletal protein, actin, and proteins that interact with actin such as myosin motor poteins and actin associated proteins Aca125 and AFAP110. We use microscopy and molecular biology as tools to dissect the fundamental mechanisms by which actin contributes to the movement of cell. Our work is relevant to the mechanisms of muscle development and cellular transformation (cancer).
Courses Taught
- BIOL 1107 Fundamentals of Biology I
- BIOL 1108 Fundamentals of Biology II
- BIOL 1101 Freshman Seminar
- BIOL 4984 Senior Seminar
- BIOL 6984 Graduate Seminar
- BIOL 2134L Cell and Molecular Biology Lab
- BIOL 4503 Biochemistry
Selected Publications
- Clump, D.A., Yu, J.J.; ChoY.J., Gao, Jett, R.J., B.S.; Zot, H., Clump, A.G., Shockey, M., Gannett, P., Coad, J.E., Shurina, R., Figg, W.D., Reed, E., and Flynn, D. (2008) A single nucleotide polymorphism in AFAP-110 enables it to efficiently activate cSrc. Cancer Cell (Submitted).
- Walker, V.G. Ammer, A., Cao, Z., Clump, A.C., Jiang, B-H, Kelley, L.C., Weed, S.A., Zot, H., and Flynn, D.C. (2007) PI -3-Kinase activation is required for PMA directed activation of cSrc by AFAP-110 Am. J. Physiol. 293: C119-32.
- Qian, Y., Gatesman, A.S. Baisden, J.M., Zot, H.G., Cherezova, L., Qazi, I., Mazloum, N., Lee, M.Y., Guappone-Koay, A., and Flynn, D.C. (2004) Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity J. Cell. Biochem. 91:602-20.Zot, H.G. and J.D. Potter (1981) Purification of actin from cardiac muscle. Prep.Biochem. 11:381-395.
- Qian, Y., Baisden, J.M., Cherezova, L., Summy, J.M., Guappone-Koay, A., Xianglin, S., Mast1, T., Pastula1, J., Zot, H.G., Mazloum, N., Lee, M.Y., and Flynn, D.C. (2002) PKC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. Mol Biol Cell. 13:2311-22.Zot, H.G. and J.D. Potter (1982) A structural role for the Ca2+-Mg2+ sites of troponin C (TnC) in the regulation of muscle contraction. Preparation and properties of TnC-depleted myofibrils. J. Biol. Chem. 257:7678-7683.
