Dr. David L. Osborne Associate Professor Physiology dosborne@westga.edu 678-839-4041

• Ph.D. in Physiology from East Carolina University School of Medicine
• M.A. in Biology from University of North Carolina/Greensboro
• B.A. in Biology /Chemistry from Elon College

My research centers around extracellular growth factors and how these growth factors may influence the growth of the lining of the intestines. A normal person living to age 70 will replace the lining of their intestines on the average of 5000-12000 times in their lifetime, depending on which part of the intestine is being discussed. Growth factors from inside our bodies as well as those derived from our environment (our diet, smoking, produced by bacteria etc.). Currently, we have several areas of investigation: 1) We are investigating the role nicotine has in regulating intestinal growth and repair to determine whether nicotine may predispose the intestines to the development of cancer, 2) We are investigating the influence of hormones related to glucose metabolism to determine if these hormones may influence the intestines in diabetic patients. 3) We are investigating the relationship of polyamines (produced by humans and bacteria) and how this family of compounds may influence growth and repair of the intestinal lining during periods of ischemia (lack of oxygen). The research involves cell culture work done at West Georgia and whole animal work performed in conjunction with Mercer University School of Medicine.

• BIOL 1010 Fundamentals of Biology
• BIOL 1107 Principles of Biology I
• BIOL 1108 Principles of Biology II
• BIOL 2021 Human Anatomy and Physiology I
• BIOL 2022 Human Anatomy and Physiology II
• BIOL 2120 Biological Computer Applications
• BIOL 3513 Human Physiology
• BIOL 3526 Vertebrate Histology
• BIOL 4503 Biological Perspectives: Biochemistry
• BIOL 4539 Comparative Physiology

• Osborne, D.L. and E.R. Seidel (1990) Gastrointestinal luminal polyamines and their enterohepatic circulation. Amer. J. Physiol. 258: G576-G584.



• Osborne, D.L., J.A. Moshier, M.S. Gesell, and G.D. Luk (1992) Polyamine uptake in tumorigenic and non-tumorigenic cell lines and the influence of extracellular putrescine on human colon cancer cells. In Dowling R.H., U.R. Folsch and C. Loser. eds. Polyamines in the Gastrointestinal Tract. Lancaster: Kluwer Academic Publishers; chapter 32: 323-334.



• Moshier, J.A., D.L. Osborne, M. Skunca, J. Dosescu, J.D. Gilbert, M. Fitzgerald, G. Polidori, R.L. Wagner, S.J. Friezner-Degen, G.D. Luk, and M.A. Flanagan (1992) Multiple promoter elements govern expression of human ornithine decarboxylase gene in colon cancer cells. Nucleic Acids Research 20 no.10: 2581-2590.



• Osborne, D.L., P.R. Carter, T.Y. AW and P.R. Kvietys (1994) Oxidant tolerance in rat small intestine: An epithelia independent event. Journal of Clinical Investigation, Vol 94: 1910-1918.



• Osborne, D.L., S. C. Payne, R.D. Russ and B.W. Tobin (2000) Comparison of therapeutic regimens in the amelioration of alterations in gastrointestinal mucosal DNA, RNA, and protein induced by streptozotocin diabetes mellitus . Life Sciences, Vol 66 no. 24: 2405-2417.