CHEM 4485W: Advanced Topics in Chemistry
Topic: Bioorganic Chemistry
Fall 2006
MWF
Instructor: Dr. Partha Ray (TLC 2-123; phone:
678-839-6023; email: psray@westga.edu)
Course
Summary: You will be introduced to
the chemistry of biologically important organic compounds and we will discus
the discovery, synthesis, and mechanism of action of a variety of selected
pharmaceutical agents. You will use, and
build on, the concepts and principles learned in general organic chemistry and see
how they are applied to the drug discovery process.
WAC
Course: This course has been
designated as a Writing Across the Curriculum
course. The writing component of this
course is designed to help you to understand and communicate the science involved
in this class. You will be required to answer several essay type questions as
part of three take home tests to fulfill the WAC requirements. The
Topics to be Covered:
Classifications
Configurations
of Monosaccharides
D, L
Sugars
Cyclic
Structures of Monosaccharides: Hemiacetal
Formation
Monosaccharide
Anomers: Mutarotation
Reactions
of monosaccharides
Di-
and Polysaccharides and Their Synthesis
Other
Important Carbohydrates
Structures
of Amino Acids
Isoelectric
Points
Synthesis
of a-Amino Acids
Peptides
and Proteins
Covalent
Bonding in Peptides
Structure
Determination of Peptides: Amino Acid Analysis
Sequencing
of Peptides: The Edman Degradation
Sequencing
of Peptides: C-Terminal Residue Determination
Synthesis
of Peptides
Automated
Peptide Synthesis: The Merrifield Solid-Phase Technique
Classification
of Proteins
Protein
Structure
Enzymes
How
Do Enzymes Work? Citrate Synthase
Protein
Denaturation
Waxes,
Fats, and Oils
Soap
Phospholipids
Prostaglandins
Terpenes
Biosynthesis
of Terpenes
Steroids
Stereochemistry
of Steroids
Steroid
Biosynthesis
Synthesis
of Terpenes and Steroids
Five-Membered Unsaturated Heterocycles:
Reactions and Synthesis
Six-Membered Unsaturated Heterocycles:
Reactions and Synthesis
Fused-Ring
Heterocycles
Structures
Base
Pairing in DNA: The Watson-Crick Model
Replication
of DNA
Structure
and Synthesis of RNA: Transcription
RNA
and Protein Biosynthesis: Translation
DNA
Sequencing
DNA
Synthesis
The
Polymerase Chain Reaction
An
Overview of Metabolism and Biochemical Energy
Catabolism
of Fats: b-Oxidation
Catabolism
of Carbohydrates: Glycolysis
The
Conversion of Pyruvate to Acetyl CoA
The
Citric Acid Cycle
Catabolism
of Proteins: Transamination
Anabolism
of Fatty Acids
Anabolism
of Carbohydrates: Gluconeogenesis
Reversible
Enzyme Inhibitors
Irreversible
Enzyme Inhibitors
DNA-Interactive
Drugs: Intercalators, Alkylators,
and
Textbook: “Organic
Chemistry” 5th or 6th edition by John McMurry.
Grade: Your grade will be based on the average from three
take home tests.
Test dates: Take Home due dates: Sept 27, Nov 1, Dec 1
Office hours: MWF:
Note: Extra credit is not allowed for this class,
and work competed for another class will not be accepted in this class. All communications outside of class should be
via campus mail (myUWG), and you are expected to
check your mail regularly.
Learning Outcomes
1. Reason and think analytically in solving
problems and making decisions in matters involving bioorganic chemistry. Attainment of this learning outcome will be
reflected by the students ability to:
Understand the reactions and synthesis of natural
products as well as the mechanism of action and synthesis of selected medicinal
agents.
2. Apply a basic understanding of the systematic
methods of scientific inquiry, principles and procedures to investigate
problems. Attainment of this learning
outcome will be reflected by the students ability to:
Use chemical logic to describe the mechanisms of new
organic reactions not covered in general organic chemistry.
3. To communicate matters of organic synthesis
with clarity. Attainment of this
learning outcome will be reflected by the students
ability to:
Successfully complete written and oral assignments, and examinations.