Biochemistry
Chemistry 4711
Fall 2006
Lecture:
Instructor: Dr. John E. Hansen
Office: Chemistry 2126; Phone:
Office
Hrs:
Text:
Lehninger
Principles of Biochemistry, 4th Edition by Nelson and Cox
Course
Objectives
CHM
4711/5611 is a semester-long biochemistry course designed for chemistry, premed
and predental students. Material covered during this
course includes structure and function of proteins, enzyme kinetics,
carbohydrates, lipids, nucleic acids and intermediary metabolism. Lectures will
follow the first 21 chapters of the text. However, material will be covered in lectures
to augment that in the text. You will be responsible for material covered in
both lectures and text.
Learning Outcomes
In this course, students will develop an understanding of the chemical basis for biological systems. They will demonstrate there understanding of the physical properties of biopolymers, complex interactions between biomolecules, enzyme kinetics, and the chemistry and regulation of metabolic pathways.
Expectations
It
is my desire that each of you will succeed
in this course. I will try to help you
in anyway I can. It is vitally important
you keep up with the material. I have found, without exception, those that
received a grade of A or B in this course have been
those that have consistently done the homework and took it seriously. Please see me if you are having
difficulties. This course will require a
minimum of six hours a week of outside studying.
The
prerequisites for this course are organic and analytical chemistry. If you had difficulties in those courses, you
will find this course particularly difficult and you will need to put forth even
more study time. NOTE: It is a requirement, and
it will be assumed, that you are fluent and very comfortable with algebra. Further, you should have had some
calculus – it will make understanding some of the principles easier.
WAC Course
Chemistry
4711 has been designated a WAC (Writing Across the
Curriculum) course. This means that
there is a writing component as part of this course that must be successfully completed to receive a passing grade. The writing requirement will consist of a
case study.
Examinations
I
will give five exams (each 50 minutes in length) throughout the semester. I
will not give makeup exams.
You will have one week from the time the exam is handed back to inquire about
the grading. After that week the grade on the exam is final. The final exam will be a comprehensive examination
(covering material throughout the course).
Grading
The
final grade will be determined from the five exams, the final exam, and case
study. Each exam will count 100 points,
the final exam 150 points. Grades will be calculated based on a maximum of 600
points.
Grade
Scale: > 90% = A; 80 - 90% = B; 70 -
80% = C; 60 - 70% = D; < 60% = F
Policies
1. You are responsible for all
material covered and all announcements made in
class. Absence
from class does not excuse or relieve you of this responsibility.
2. Cheating will not be
tolerated. On the first occurrence it
will result in a grade of zero
for the exercise
in question. A second occurrence will
result in a grade of F for the
course. All out of class assignments will be done in
the absence of any collaboration
from others. Any questions, clarifications, or requests
for assistance should be directed
only to me.
3. No make-up exams will be
given. Anyone not able to take an exam on the day
scheduled must
contact me before the exam.
4.
Your attendance at all class times is critical to your success in this
course. I reserve the
right to withdraw
you from class roles due to flagrant absences or tardiness.
5.
NO
entering the
classroom, you will place your cell phones in your backpacks and leave them
there until after
class. Violation of this rule will result
in immediate dismissal from that
day’s class, if
during an exam – a grade of zero.
TENTATIVE SCHEDULE
Chapters
8/14 Introduction: Biomolecules, Weak Acids, Amino Acids
8/16 Amino Acids and Peptides
8/21 Protein Structure
8/23 Protein Structure and
Purification
8/25 Myoglobin
& Hemoglobin
8/28 Protein Structure & Enzymes
8/30 Exam I
9/01 Enzyme Reactions and Enzyme
Kinetics
9/06 Enzyme Inhibition
9/08 Bisubstrate kinetics, allosterism , & regulation
9/11 Carbohydrates
9/13 Carbohydrates
9/15 Nucleic Acids
9/18 Lipids
9/20 Exam II
9/22 Membranes
9/25 Transport
9/27 Biosignaling
9/29 Bioenergetics
10/02 Glycolysis
I
10/04 Glycolysis
II
10/06 Fate of Pyruvate
/ Entry of other carbohydrates into glycolysis
10/11 Exam III & First Draft of Case Study Due
10/13 Regualtion
of glycolysis
10/16 Pentose Phosphate
10/18 Pyruvate
Dehydrogenase Complex and Cirtic
Acid Cycle I
10/20 Citric Acid Cycle II
10/23 Regulation/
10/25 Electron Transport
10/27 Oxidative Phosphorylation
10/30 Exam IV
11/01 Lipid Metablism
11/03 Fatty Acid Oxidation
11/06 Fatty Acid Oxidation
11/08 Ketone
Body formation/ Regulation
11/10 Urea cycle
11/13 Amino acid oxidation
11/15 Amino acid oxidation
11/17 Gluconeogenesis/
regulation
11/20 Exam V
11/27 Glycogen Biosynthesis &
Regulation/ Lipid Biosynthesis
11/29 Synthesis of Fatty acids and
triglycerides
SUPPLEMENTARY TEXTS (recommended, not required)
Schaum’s Outline Series Theory and Problems of Biochemistry, McGraw Hill
Book Co. 1988.
BIOCHEMISTRY by Stryer
BIOCHEMISTRY
by Voet and Voet
BIOCHEMICAL CALCULATIONS by Segel
PRINCIPLES OF BIOCHEMISTRY
by White, Handler and Smith
PROTEINS
by Creighton
ENZYME STRUCTURE